Key Publications

  1. Lobachevsky, P.N., Ventura, J., Giannakandropoulou, L., Forrester, H., Palazzolo, J.S., Haynes, N.M., Stevenson, A.W., Hall, C.J., Mason, J., Pollakis, G. et al. (2019) A Functional Immune System Is Required For The Systemic Genotoxic Effects Of Localised Irradiation. International Journal of Radiation Oncology*Biology*Physics, 103 1184-1193.
  2. Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N.N., Glytsou, C., Pateras, I.S., Swain, U., Souliotis, V.L. et al. (2018) Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biology, 19, 37.
  3. Ventura, J., Lobachevsky, P.N., Palazzolo, J.S., Forrester, H., Haynes, N.M., Ivashkevich, A., Stevenson, A.W., Hall, C.J., Ntargaras, A., Kotsaris, V. et al. (2017) Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses. Cancer Res, 77, 6389-6399.
  4. Pavlopoulou, A., Bagos, P.G., Koutsandrea, V. and Georgakilas, A.G. (2017) Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach. Cancer Lett, 403, 37-47. Mavragani, I., Nikitaki, Z., Souli, M., Aziz, A., Nowsheen, S., Aziz, K., Rogakou, E. and Georgakilas, A. (2017) Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis. Cancers, 9, 91.
  5. Georgakilas, A.G., Martin, O.A. and Bonner, W.M. (2017) p21: A Two-Faced Genome Guardian. Trends Mol Med, 23, 310-319.
  6. Nikitaki, Z., Nikolov, V., Mavragani, I.V., Mladenov, E., Mangelis, A., Laskaratou, D.A., Fragkoulis, G.I., Hellweg, C.E., Martin, O.A., Emfietzoglou, D. et al. (2016) Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET). Free Radic Res, 50, S64-S78.
  7. Nikitaki, Z., Mavragani, I.V., Laskaratou, D.A., Gika, V., Moskvin, V.P., Theofilatos, K., Vougas, K., Stewart, R.D. and Georgakilas, A.G. (2016) Systemic mechanisms and effects of ionizing radiation: A new ‘old’ paradigm of how the bystanders and distant can become the players. Semin Cancer Biol, 37-38, 77-95.
  8. Bignon, E., Gattuso, H., Morell, C., Dehez, F., Georgakilas, A.G., Monari, A. and Dumont, E. (2016) Correlation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion. Nucleic Acids Res, 44, 8588-8599.
  9. Pateras, I.S., Havaki, S., Nikitopoulou, X., Vougas, K., Townsend, P.A., Panayiotidis, M.I., Georgakilas, A.G. and Gorgoulis, V.G. (2015) The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where.Pharmacol Ther, 154, 36-56.
  10. Nikitaki, Z., Hellweg, C.E., Georgakilas, A.G. and Ravanat, J.L. (2015) Stress-induced DNA damage biomarkers: applications and limitations. Frontiers in chemistry, 3, 35.
  11. Hatzi, V.I., Laskaratou, D.A., Mavragani, I.V., Nikitaki, Z., Mangelis, A., Panayiotidis, M.I., Pantelias, G.E., Terzoudi, G.I. and Georgakilas, A.G. (2015) Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology. Cancer Lett, 356, 34-42.
  12. Georgakilas, A.G., O’Neill, P. and Stewart, R.D. (2013) Induction and repair of clustered DNA Lesions: What do we know so far? Radiat. Res., 180, 100–109.
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Recent publications

2023

  1.  Logotheti, S.; Georgakilas, A.G. (2023) More than meets the eye: Integration of radiomics with transcriptomics for reconstructing the tumor microenvironment and predicting response to therapy. Cancers 2023, 15, 1634.

2022

  1. Elisa Posani , Maddalena Dilucca , Sergio Forcelloni , Athanasia Pavlopoulou , Alexandros G Georgakilas , Andrea Giansanti (2022) Temporal evolution and adaptation of SARS-CoV-2 codon usage, 27(1):13.
  2. Marina Chalkia , Nikolaos-Achilleas Arkoudis , Emmanouil Maragkoudakis , Stamatis Rallis , Ioanna Tremi , Alexandros G Georgakilas , Vassilis Kouloulias , Efstathios Efstathopoulos , Kalliopi Platoni (2022) The Role of Ionizing Radiation for Diagnosis and Treatment against COVID-19: Evidence and Considerations, 11(3):467.
  3. Zacharenia Nikitaki , Anastasia Velalopoulou , Vassiliki Zanni , Ioanna Tremi , Sophia Havaki , Michael Kokkoris , Vassilis G Gorgoulis , Constantinos Koumenis , Alexandros G Georgakilas (2022) Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair, 24:e15.
  4. Panagiotis Galanos , George Pappas , Alexander Polyzos , Athanassios Kotsinas , Ioanna Svolaki , Nickolaos N Giakoumakis , Christina Glytsou , Ioannis S Pateras , Umakanta Swain , Vassilis L Souliotis , Alexandros G Georgakilas , Nicholas Geacintov , Luca Scorrano , Claudia Lukas , Jiri Lukas , Zvi Livneh , Zoi Lygerou , Dipanjan Chowdhury , Claus Storgaard Sørensen , Jiri Bartek , Vassilis G Gorgoulis (2022) Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability, 23(1):107.
  5. Anastasios I Birmpilis , Antonios Paschalis , Apostolis Mourkakis , Panayiota Christodoulou , Ioannis V Kostopoulos , Elina Antimissari , Georgia Terzoudi , Alexandros G Georgakilas , Christina Armpilia , Panagiotis Papageorgis , Efstathios Kastritis , Evangelos Terpos , Meletios A Dimopoulos , Hubert Kalbacher , Evangelia Livaniou , Maria-Ioanna Christodoulou , Ourania E Tsitsilonis (2022) Immunogenic Cell Death, DAMPs and Prothymosin α as a Putative Anticancer Immune Response Biomarker, 11(9):1415.
  6. Mehtap Ozkur , Necla Benlier , Işıl Takan , Christina Vasileiou , Alexandros G Georgakilas , Athanasia Pavlopoulou , Zafer Cetin , Eyup Ilker Saygili (2022) Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties, 2022: 4748447.
  7. Fernandez-Palomo, C.; Nikitaki, Z.; Djonov, V.; Georgakilas, A.G.; Martin, O.A. (2022) Non-targeted effects of synchrotron radiation: Lessons from experiments at the australian and european synchrotrons, Applied Sciences, 2022: 12, 2079.
  8.  Logotheti, S.; Pavlopoulou, A.; Marquardt, S.; Takan, I.; Georgakilas, A.G.; Stiewe, (2022) T. P73 isoforms meet evolution of metastasis. Cancer Metastasis Rev 2022.
  9. Makrantoni, P.; Tezari, A.; Stassinakis, A.N.; Paschalis, P.; Gerontidou, M.; Karaiskos, P.; Georgakilas, A.G.; Mavromichalaki, H.; Usoskin, I.G.; Crosby, N., et al. (2022) Estimation of cosmic-ray-induced atmospheric ionization and radiation at commercial aviation flight altitudes. Applied Sciences 2022, 12, 5297.
  10. Sagkrioti, E.; Biz, G.M.; Takan, I.; Asfa, S.; Nikitaki, Z.; Zanni, V.; Kars, R.H.; Hellweg, C.E.; Azzam, E.I.; Logotheti, S., et al. (2022) Radiation type- and dose-specific transcriptional responses across healthy and diseased mammalian tissues. Antioxidants 2022, 11, 2286.
  11. Souli, M.P.; Nikitaki, Z.; Puchalska, M.; Brabcová, K.P.; Spyratou, E.; Kote, P.; Efstathopoulos, E.P.; Hada, M.; Georgakilas, A.G.; Sihver, L. (2022) Clustered DNA damage patterns after proton therapy beam irradiation using plasmid DNA. International Journal of Molecular Sciences 2022, 23, 15606.
  12. Spyratou, E.; Ploussi, A.; Alafogiannis, P.; Katifelis, H.; Apostolopoulou, S.; Bagenakis, G.; Rammos, S.; Papagiannis, I.; Gazouli, M.; Seimenis, I., et al. (2022) Fdxr gene expression after in vivo radiation exposure of pediatric patients undergoing interventional cardiology procedures. Frontiers in Bioscience Landmark Edition 2022, 27, 255-261.
  13. Tremi, I.; Havaki, S.; Georgitsopoulou, S.; Terzoudi, G.; Lykakis, I.N.; Iliakis, G.; Georgakilas, V.; Gorgoulis, V.G.; Georgakilas, A.G. (2022) Biological response of human cancer cells to ionizing radiation in combination with gold nanoparticles. Cancers 2022, 14, 5086.

2021

  1. Katalin Lumniczky , Nathalie Impens , Gemma Armengol , Serge Candéias , Alexandros G Georgakilas , Sabine Hornhardt , Olga A Martin , Franz Rödel , Dörthe Schaue (2021) Low dose ionizing radiation effects on the immune system, 149:106212.
  2. Theodora-Dafni Michalettou , Ioannis Michalopoulos , Sylvain V Costes , Christine E Hellweg , Megumi Hada , Alexandros G Georgakilas (2021) A Meta-Analysis of the Effects of High-LET Ionizing Radiations in Human Gene Expression, 11(2):115.
  3. Spyridon A Kalospyros , Zacharenia Nikitaki , Ioanna Kyriakou , Michael Kokkoris , Dimitris Emfietzoglou , Alexandros G Georgakilas (2021) A Mathematical Radiobiological Model (MRM) to Predict Complex DNA Damage and Cell Survival for Ionizing Particle Radiations of Varying Quality, 26(4):840.
  4. Ioanna Kyriakou , Ioanna Tremi , Alexandros G Georgakilas , Dimitris Emfietzoglou (2021) Microdosimetric investigation of the radiation quality of low-medium energy electrons using Geant4-DNA, 172:109654.
  5. Pataje G Prasanna , Deborah E Citrin , Jeffrey Hildesheim , Mansoor M Ahmed , Sundar Venkatachalam , Gabriela Riscuta , Dan Xi , Guangrong Zheng , Jan van Deursen , Jorg Goronzy , Stephen J Kron , Mitchell S Anscher , Norman E Sharpless , Judith Campisi , Stephen L Brown , Laura J Niedernhofer , Ana O’Loghlen , Alexandros G Georgakilas , Francois Paris , David Gius , David A Gewirtz , Clemens A Schmitt , Mohamed E Abazeed , James L Kirkland , Ann Richmond , Paul B Romesser , Scott W Lowe , Jesus Gil , Marc S Mendonca , Sandeep Burma , Daohong Zhou , C Norman Coleman (2021) Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy, 113(10):1285-1298.
  6. Ioanna Tremi , Sophia Havaki , Sofia Georgitsopoulou , Nefeli Lagopati , Vasilios Georgakilas , Vassilis G Gorgoulis , Alexandros G Georgakilas (2021) A Guide for Using Transmission Electron Microscopy for Studying the Radiosensitizing Effects of Gold Nanoparticles In Vitro, 11(4):859.
  7. Halil Ibrahim Toy , Gökhan Karakülah , Panagiota I Kontou , Hani Alotaibi , Alexandros G Georgakilas , Athanasia Pavlopoulou (2021) Investigating Molecular Determinants of Cancer Cell Resistance to Ionizing Radiation Through an Integrative Bioinformatics Approach, 9:620248.
  8. Zoi Spyropoulou , Angelos Papaspyropoulos , Nefeli Lagopati , Vassilios Myrianthopoulos , Alexandros G Georgakilas , Maria Fousteri , Athanassios Kotsinas , Vassilis G Gorgoulis (2021) Cockayne Syndrome Group B (CSB): The Regulatory Framework Governing the Multifunctional Protein and Its Plausible Role in Cancer, 10(4):866.
  9. Ioanna Tremi , Ellas Spyratou , Maria Souli , Efstathios P Efstathopoulos , Mersini Makropoulou , Alexandros G Georgakilas , Lembit Sihver (2021) Requirements for Designing an Effective Metallic Nanoparticle (NP)-Boosted Radiation Therapy (RT), 13(13):3185.
  10. Zacharenia Nikitaki , Evangelia Choulilitsa , Spyridon A Kalospyros , Sofia Kaisaridi , Georgia I Terzoudi , Mike Kokkoris , Alexandros G Georgakilas (2021) Construction and evaluation of an α-particle-irradiation exposure apparatus, 97(10):1404-1416.
  11. Paris T Moumoulidis , Athanasia Pavlopoulou , Reşat Ünal , Ifigeneia Mavragani , Alexandros G Georgakilas , Efthymios Kyrodimos (2021) Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review, 26(7):235-245.
  12. Martha Habibi , Panagiotis K Karyofyllis , Aggeliki Nikolakopoulou , Panagiotis Papagiannis , Pantelis Karaiskos , Alexandros G Georgakilas , Vasiliki I Hatzi , Ioannis Malakos , Nikolaos Kollaros , Irene Mastorakou , Vassilis Voudris , Georgia I Terzoudi (2021) The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology, 9:701878.
  13. Dionysia Theofylaktou , Işıl Takan , Gökhan Karakülah , Gökay Mehmet Biz , Vaso Zanni , Athanasia Pavlopoulou , Alexandros G Georgakilas (2021) Mining Natural Products with Anticancer Biological Activity through a Systems Biology Approach, 2021:9993518.
  14. Aikaterini Louka , Işıl Takan , Athanasia Pavlopoulou , Alexandros G Georgakilas (2021) Bioinformatic approaches to the investigation of the atavistic genes implicated in cancer, 26(8):279-311.
  15. Athanasia Pavlopoulou , Seyedehsadaf Asfa , Evangelos Gioukakis , Ifigeneia V Mavragani , Zacharenia Nikitaki , Işıl Takan , Jean-Pierre Pouget , Lynn Harrison , Alexandros G Georgakilas (2021) In Silico Investigation of the Biological Implications of Complex DNA Damage with Emphasis in Cancer Radiotherapy through a Systems Biology Approach, 26(24):7602.
  16. Soile Tapio , Mark P Little , Jan Christian Kaiser , Nathalie Impens , Nobuyuki Hamada , Alexandros G Georgakilas , David Simar , Sisko Salomaa (2021) Ionizing radiation-induced circulatory and metabolic diseases. Environ Int , 146:106235.

2020

  1. Kanakoglou DS, Michalettou TD, Vasileiou C, Gioukakis E, Maneta D, Kyriakidis KV, Georgakilas AG, Michalopoulos I. (2020)  Effects of High-Dose Ionizing Radiation in Human Gene Expression: A Meta-Analysis. International Journal of  Molecular Sciences. 21(6)
  2. Dilucca M, Pavlopoulou A,Georgakilas AG, Giansanti A. (2020) Codon usage bias in radioresistant bacteria. Gene:144554. doi: 10.1016/j.gene.2020.144554.
  3. Margis S, Magouni M, Kyriakou I,Georgakilas AG, Incerti S, Emfietzoglou D. (2020) Microdosimetric calculations of the direct DNA damage induced by low energy electrons using the Geant4-DNA Monte Carlo code. Physics in Medicine and Biology. 65(4)
  4. Konstantinos P Chatzipapas , Panagiotis Papadimitroulas , Dimitris Emfietzoglou , Spyridon A Kalospyros , Megumi Hada , Alexandros G Georgakilas , George C Kagadis (2020) Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations, 12(4):799.
  5. Maddalena Dilucca , Sergio Forcelloni , Alexandros G Georgakilas , Andrea Giansanti , Athanasia Pavlopoulou (2020) Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes, 12(5):498.
  6. Franz Rödel , Meritxell Arenas , Oliver J Ott , Claudia Fournier , Alexandros G Georgakilas , Soile Tapio , Klaus-Rüdiger Trott , Udo S Gaipl (2020) Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?, 196(8):679-682.
  7. Georgios Kareliotis , Ioanna Tremi , Myrsini Kaitatzi , Eleni Drakaki , Alexandros A Serafetinides , Mersini Makropoulou , Alexandros G Georgakilas (2020) Combined radiation strategies for novel and enhanced cancer treatment, 96(9):1087-1103.
  8. Antonio Pantelias , Demetre Zafiropoulos , Roberto Cherubini , Lucia Sarchiapone , Viviana De Nadal , Gabriel E Pantelias , Alexandros G Georgakilas , Georgia I Terzoudi (2020) Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering-A Critical Risk for Chromothripsis, 12(9):2336.
  9. Zacharenia Nikitaki , Eloise Pariset , Damir Sudar , Sylvain V Costes , Alexandros G Georgakilas (2020) In Situ Detection of Complex DNA Damage Using Microscopy: A Rough Road Ahead, 12(11):3288.

2019

  1. Ventura, J., Sprung, C.N., Forrester, H.B., Palazzolo, J.S., Ivashkevich, A., Stevenson, A.W., Hall, C.J., Georgakilas, A.G., Lobachevsky, P.N. and Martin, O.A. (2019) Micro-Mini & Nano Dosimetry (MMND) 2018, 6–11 February 2018, Mooloolaba, Queensland, Australia: Systemic effects of synchrotron radiation. Journal of Physics: Conference Series, 1154, 012028.
  2. Lobachevsky, P.N., Ventura, J., Giannakandropoulou, L., Forrester, H., Palazzolo, J.S., Haynes, N.M., Stevenson, A.W., Hall, C.J., Mason, J., Pollakis, G. et al. (2019) A Functional Immune System Is Required For The Systemic Genotoxic Effects Of Localised Irradiation. International Journal of Radiation Oncology*Biology*Physics, 103 1184-1193.
  3. Dimitriou, N.M., Pavlopoulou, A., Tremi, I., Kouloulias, V., Tsigaridas, G. and Georgakilas, A.G. (2019) Prediction of Gold Nanoparticle and Microwave-Induced Hyperthermia Effects on Tumor Control via a Simulation Approach. Nanomaterials, 9, 167-186.
  4. Toy, H.I., Okmen, D., Kontou, P.I., Georgakilas, A.G. and Pavlopoulou, A. (2019) HOTAIR as a Prognostic Predictor for Diverse Human Cancers: A Meta- and Bioinformatics Analysis. Cancers, 11, 778.
  5. Pavlopoulou, A., Karaca, E., Balestrazzi, A. and Georgakilas, A.G. (2019) In Silico Phylogenetic and Structural Analyses of Plant Endogenous Danger Signaling Molecules upon Stress. Oxidative Medicine and Cellular Longevity, 2019, 14.
  6. Pantelias, A., Karachristou, I., Georgakilas, A.G. and Terzoudi, G.I. (2019) Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis. Cancers, 11, 1123.
  7. Myrianthopoulos, V., Evangelou, K., Vasileiou, P.V.S., Cooks, T., Vassilakopoulos, T.P., Pangalis, G.A., Kouloukoussa, M., Kittas, C., Georgakilas, A.G. and Gorgoulis, V.G. (2019) Senescence and senotherapeutics: a new field in cancer therapy. Pharmacology & Therapeutics, 193, 31-49.
  8. Mavragani, I.V., Nikitaki, Z., Kalospyros, S.A. and Georgakilas, A.G. (2019) Ionizing Radiation and Complex DNA Damage: From Prediction to Detection Challenges and Biological Significance. Cancers, 11, 1789.
  9. Düzgün , M.B., Theofilatos, K., Georgakilas, A.G. and Pavlopoulou, A. (2019) A Bioinformatic Approach for the Identification of Molecular Determinants of Resistance/Sensitivity to Cancer Thermotherapy. Oxidative Medicine and Cellular Longevity, 2019, 13.

2018

  1. Ventura, J., Lobachevsky, P., Palazzolo, J., Forrester, H., Haynes, N., Ivashkevich, A., Stevenson, A., Hall, C., Gorgoulis, V., Hamilton, J. et al. (2018) Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. Abstract 4573: Localized synchrotron radiation in mice induces persistent systemic genotoxic events mediated by the functional immune system. Cancer Research, 78, 4573.
  2. Tremi, I., Anagnostopoulos, D., Spyratou, E., Gkeka, P., Georgakilas, A.G., Chatgilialoglu, C. and Cournia, Z. (2018) Effect of 5-trans Isomer of Arachidonic Acid on Model Liposomal Membranes Studied by a Combined Simulation and Experimental Approach. The Journal of membrane biology, 251, 475-489.
  3. Pouget, J.P., Georgakilas, A.G. and Ravanat, J.L. (2018) Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk-Benefit Analysis. Antioxid Redox Signal.
  4. Nikolaou, M., Pavlopoulou, A., Georgakilas, A.G. and Kyrodimos, E. (2018) The challenge of drug resistance in cancer treatment: a current overview. Clinical & experimental metastasis.
  5. Nikitaki, Z., Hola, M., Dona, M., Pavlopoulou, A., Michalopoulos, I., Angelis, K.J., Georgakilas, A.G., Macovei, A. and Balestrazzi, A. (2018) Integrating plant and animal biology for the search of novel DNA damage biomarkers. Mutat Res, 775, 21-38.
  6. Myrianthopoulos, V., Evangelou, K., Vasileiou, P.V.S., Cooks, T., Vassilakopoulos, T.P., Pangalis, G.A., Kouloukoussa, M., Kittas, C., Georgakilas, A.G. and Gorgoulis, V.G. (2018) Senescence and senotherapeutics: a new field in cancer therapy. Pharmacol Ther.
  7. Katsiki, A., Karatzas, P., Georgakilas, A.G. and C., V. (2018), Poster presentation at: ECCB18 – 17th European Conference on Computational biology; 2018 Sep 8-12; Athens, Greece.
  8. Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N.N., Glytsou, C., Pateras, I.S., Swain, U., Souliotis, V.L. et al. (2018) Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biology, 19, 37.
  9. Fragopoulou, A.F., Polyzos, A., Papadopoulou, M.D., Sansone, A., Manta, A.K., Balafas, E., Kostomitsopoulos, N., Skouroliakou, A., Chatgilialoglu, C., Georgakilas, A. et al. (2018) Hippocampal lipidome and transcriptome profile alterations triggered by acute exposure of mice to GSM 1800 MHz mobile phone radiation: An exploratory study. Brain and behavior, 8, e01001.180, 100–109.