DNA damage - Role of clustered DNA damage in carcinogenesis

Radiation exposure can lead to DNA damage consisting of isolated and clustered DNA lesions (OCDLs), release of proinflammatory cytokines and chemokines, reactive oxygen and nitrogen species (ROS/RNS). The final outcome can be persistent DNA damage in the cells, chronic inflammation and tissue injury. All these conditions can lead to genomic instability and therefore are considered as precursors of carcinogenesis.

PNAS Article 2010

From the Cover

Tumors induce complex DNA damage in distant proliferative tissues in vivo

See commentary ''Long-distance inflammatory and genotoxic impact of cancer in vivo'' on page 17861.

See commentary ''Para-inflammation mediates systematic DNA damage in response to tumor growth'' in Commun Integr Biol, volume 4 on page 78.